The majority of the investment will be channelled into developments in small and medium sized towns, but will also include larger towns and cities.
These are set to include new pubs in Bourne, Waterford, Hamilton, Ely, Diss, Felixstowe, Newport Pagnell and Prestatyn.
It will also be investing in major cities including London, Dublin, Edinburgh, Glasgow, Birmingham, Leeds and Galway.
Wetherspoon founder and chairman Tim Martin (pictured) said, “ We are looking forward to opening many more new pubs as well as investing in existing pubs over the next four years.
“We are especially pleased that a large proportion of the investment will be in smaller towns and cities which have seen a decline in investment in recent years.
“The fact that we will be creating approximately 10,000 jobs is great news too.”
Wetherspoon operates 875 pubs and 58 hotels across the UK and Republic of Ireland and employs 44,000 staff.